Dulaglutide-based alternative Dulaglutide is a weekly injectable GLP-1, available under the brand name Trulicity
They are not recommended in those with personal or family history of multiple endocrine neoplasia 2A, multiple endocrine neoplasia 2B, or medullary thyroid cancer due to concern for long-term thyroid effects.3 Side Effects and their Implications in the ED Gastrointestinal Side effects Mild gastrointestinal side effects are most common with patients experiencing nausea (25-40%), vomiting, diarrhoea, or constipation.3,4 Rarer, more serious presentations include pancreatitis, bowel obstruction, gallbladder disease, which should be actively managed in the ED.3,5 Hypersensitivity reaction These reactions are commonly associated with self-limiting or antihistaminic responsive pruritic rash
The medication works by activating GLP-1 receptors in the brain, which leads to a decrease in food intake and an increase in feelings of fullness
This means weight and height must be measured and recorded at the visit where tirzepatide is prescribed or administered
However, it may take several weeks or even months to see the full effects on your blood sugar (HbA1c) and weight